988-7 Endothelin ET A/B Receptor Antagonist Reduces Infarct Size: A Novel Therapy for Acute Myocardial Infarction
نویسندگان
چکیده
منابع مشابه
Circadian variations of infarct size in acute myocardial infarction.
BACKGROUND The circadian clock influences a number of cardiovascular (patho)physiological processes including the incidence of acute myocardial infarction. A circadian variation in infarct size has recently been shown in rodents, but there is no clinical evidence of this finding. OBJECTIVE To determine the impact of time-of-day onset of ST segment elevation myocardial infarction (STEMI) on in...
متن کاملDeterminants of infarct size in reperfusion therapy for acute myocardial infarction.
BACKGROUND Experimental animal studies have demonstrated that myocardium at risk, residual collateral flow, and duration of coronary artery occlusion are important determinants of final infarct size. The present study examined these variables in patients with acute myocardial infarction in relation to final infarct size. METHODS AND RESULTS Myocardium at risk was assessed with hexakis(2-metho...
متن کاملEnzymatic infarct size and its significance for evaluation of thrombolytic therapy after acute myocardial infarction.
The February 1990 issue of Circulation contained an editorial comment by Dr. R. Roberts1 concerning our study on enzyme recovery from dog heart.2 We appreciate Roberts' interest in our study, and we agree with him that there is urgent need for methods allowing quantitative estimation of myocardial injury. We feel, however, that some of Roberts' remarks could cause confusion regarding the implic...
متن کاملInfarct Size in Awake Dogs With Acute Myocardial Infarction
Background. Short-term cholesterol feeding has been shown to affect vasomotor tone and increase infarct size in anesthetized rabbits. The purpose of the study was to determine whether acute hypercholesterolemia reduced collateral flow to ischemic myocardium and increased infarct size in the awake dog. Methods and Results. Acute myocardial infarction was produced in awake dogs by a 4-hour left a...
متن کاملAcute Myocardial Infarction Early Interleukin-1 Receptor Antagonist Elevation in Patients With Acute Myocardial Infarction
OBJECTIVES We sought to evaluate interleukin-1 receptor antagonist (IL-1Ra) levels in patients with ST-segment elevation acute myocardial infarction (AMI) upon emergency department (ED) admission in order to assess the sensitivity of such a determination by comparison with common markers of myocardial necrosis. BACKGROUND Inflammatory markers are elevated in patients with unstable coronary synd...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 1995
ISSN: 0735-1097
DOI: 10.1016/0735-1097(95)92747-s